COMBINATION OF ACTIVE INGREDIENTS FOR THE TREATMENT OF SENILE DEMENTIA OF THE ALZHEIMER TYPE

摘要

Pharmaceutical compositions containing a tetrahydropyridine derivative of formula (I) and an acetylcholinesterase inhibitor (II) are new: Y = CH or N; R1 = H, halo, CF3, 3-4C alkyl or 1-4C alkoxy; R2 = H, halo, OH, CF3, 3-4C alkyl or 1-4C alkoxy; R3 and R4 = H or 1-3C alkyl; X = (a) 3-6C alkyl, 3-6C alkoxy, 3-7C carboxyalkyl, (2-5C)alkoxycarbonyl(1-4C)alkyl, 3-7C carboxyalkoxy or (2-5C)alkoxycarbonyl(1-4C)alkoxy; (b) 3-7C cycloalkyl, 3-7C cycloalkoxy, (3-7C cycloalkyl)methyl, 3-7C cycloalkylamino or cyclohexenyl, all optionally substituted by halo, OH, 1-4C alkoxy, COOH, 2-5C alkoxycarbonyl, NH2 or mono- or di(1-4C alkyl)amino; or (c) phenyl, phenoxy, phenylamino, N-(1-3C alkyl)-phenylamino, benzyl, phenylethyl, benzoyl, phenylthio, phenylsulphonyl, phenylsulphinyl or styryl, all optionally ring-substituted by halo, 1-4C alkyl, 1-4C alkoxy, CN, NH2, mono- or di(1-4C alkyl)amino, 1-4C acylamino, COOH, 2-5C alkoxycarbonyl, CONH2, mono- or di(1-4C alkyl)carbamoyl, 1-4C aminoalkyl, 1-4C hydroxyalkyl, CF3 or 1-4C haloalkyl.