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Regulatory nucleotide sequence of the initiation of transcription

机译:转录起始的调控核苷酸序列

摘要

The invention relates to a recombinant nucleotide sequence, characterized in that it comprises:PPa regulatory sequence of the initiation of tanscription, this regulatory sequence containing a promoter in association with the motif GCACTC 9N GAGTGC, in which "N" signifies any one of the 4 bases thymine, guanine, adenine and cytosine; PPa sequence coding for a polypeptide, called "heterologous polypeptide", which is different from that naturally associated with the said promoter;PPthe said coding sequence being positioned downstream from the said regulatory sequence of the initiation of transcription at a site which, under suitable conditions, would allow the expression of the polypeptide under the control of the said promoter.
机译:本发明涉及重组核苷酸序列,其特征在于它包含:P光起始的调控序列,该调控序列包含与基序GCACTC 9N GAGTGC相关的启动子,其中“ N”表示4个碱基的胸腺嘧啶,鸟嘌呤,腺嘌呤和胞嘧啶中的任何一种;

编码多肽的序列,称为“异源多肽”,与天然与所述启动子相关的序列不同;

所述编码序列位于多肽的所述调控序列的下游。在合适条件下,在允许在启动子控制下表达多肽的位点开始转录。

著录项

  • 公开/公告号US6153404A

    专利类型

  • 公开/公告日2000-11-28

    原文格式PDF

  • 申请/专利权人 INSTITUT PASTEUR;

    申请/专利号US19980031606

  • 发明设计人 GERARD GUGLIELMI;PHILIPPE MAZODIER;

    申请日1998-02-27

  • 分类号C12N15/11;C12N15/63;C12N1/20;C07H21/04;

  • 国家 US

  • 入库时间 2022-08-22 01:06:28

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