Use of purine receptor agonists to alleviate or normalize physiopathologically excited sensory nerve function

摘要

A method for the alleviation or normalization (i.e., treatment) of physiopathologically excited sensory nerve function (i.e., pain) comprising the administration of a purine receptor agonist in an effective amount to a mammal other than a rodent. In a preferred embodiment, pain is treated in a human by the administration of an effective amount of a purine receptor agonist. In an alternative embodiment, an adenosine compound, such as but not limited to adenosine or adenosine triphosphate, is administered in an effective amount to a human to treat surgical pain, chronic pain, and/or traumatic pain. Human patients receiving a continuous infusion of an adenosine compound during surgery reported a profound analgesic effect after surgery.