Analysis of Sensory Evoked Potentials Using Normalized Cross-Correlation Functions and Polyexponential Regression.

摘要

Somatosensory evoked potentials (EPs) produced by stimulation of the dorsal columns were recorded from the cervico-medullary junction of adult Rhesus, and were analysed using normalized cross-correlation functions (NCCFs), simple peak-detection, and RMS amplitude measurement. The NCCF provided measures of latency shift and waveshape change, while the more traditional peak-detection method provided measures of peak latency and peak amplitude. The results of these procedures were plotted as functions of time relative to a single, brief experimental manipulation (impact acceleration of the whole body). Analysis by means of the NCCF was found to be versatile and effective technique, the advantages of which include: measurement of latency shifts with little contamination by moderate changes in waveshape, quantification of subtle waveshape changes, and usefulness under a wide variety of noise conditions. Polyexponential regression analyses were performed on selected plots and were found to be an effective means of reducing of these data.