3-substituted pyrido4,3:4,5thieno2,3-dpyrimidine derivatives, their preparation and their use

摘要

A 3-substituted 3,4,5,6,7,8-hexahydropyrido4,3:4,5thieno2,3-dpyrimidine compound of formula I ;wherein;R¹ is hydrogen, C₁-C₄-alkyl, acetyl or benzoyl, optionally substituted phenyl-C₁-C₄-alkyl, naphthyl-C₁-C₃-alkyl, phenyl-C₂-C₃-alkanone or a phenylcarbamoyl-C₂-alkyl,;R² is optionally substituted phenyl, pyridyl, pyrimidyl or pyrazinyl, or an optionally substituted bicyclus wherein one of the two fused rings is a phenyl, a pyridyl, a pyrimidyl or a pyrazinyl ring,;A is NH or oxygen,;B is hydrogen or methyl,;C is hydrogen, methyl or hydroxyl,;X is nitrogen,;Y is CH₂, CH₂C₂, CH₂C₂CH₂ or CH₂CH,;Z is nitrogen, C or CH, and the linkage between Y and Z is a single or a double bond, and;n is 2, 3 or 4,;or a physiologically tolerated salt thereof, and compositions comprising them and their use as antagonists of 5HT_1B and 5HT_1A and for the treatment of depression and related disorders.