NEW ANGIOSTATIN-CONVERTING ENZYME, MICROORGANISM PRODUCING THE ENZYME, METHOD FOR PRODUCING THE ENZYME, AND METHOD FOR PRODUCING ANGIOSTATIN AND ACTIVE SERINE PROTEASE BY UTILIZING THE ENZYME

摘要

PROBLEM TO BE SOLVED: To provide a new angiostatin-converting enzyme, a microorganism producing the enzyme, a method for producing the enzyme, and the application as an activating agent of the enzyme.;SOLUTION: The producing microorganism is Bacillus megaterium A9542 strain (accession number: FERM P-18268). Bacillomycin MA of the enzyme produced by the microorganism, the gene of the microorganism, a neovascularization inhibitor containing an angiostatin-like fragment produced from a plasminogen by the action of the enzyme as an active ingredient, the activator of a plasma serine protease group containing the enzyme as an active ingredient, and a method for producing an angiostatin-like molecule and mini- plasminogen-like molecule by subjecting a plasminogen to limited digestion by using the enzyme are also provided.;COPYRIGHT: (C)2002,JPO