Producing bacteria angiostatin converting enzyme novel, of the enzyme, the production method of the enzyme, the production of active serine protease and angiostatin by use of the enzyme

摘要

PROBLEM TO BE SOLVED: To provide a new angiostatin-converting enzyme, a microorganism producing the enzyme, a method for producing the enzyme, and the application as an activating agent of the enzyme. SOLUTION: The producing microorganism is Bacillus megaterium A9542 strain (accession number: FERM P-18268). Bacillomycin MA of the enzyme produced by the microorganism, the gene of the microorganism, a neovascularization inhibitor containing an angiostatin-like fragment produced from a plasminogen by the action of the enzyme as an active ingredient, the activator of a plasma serine protease group containing the enzyme as an active ingredient, and a method for producing an angiostatin-like molecule and mini- plasminogen-like molecule by subjecting a plasminogen to limited digestion by using the enzyme are also provided.