GRAPHICAL MODELING METHOD AND DEVICE FOR INFERRING GENE NETWORK

摘要

PROBLEM TO BE SOLVED: To provide graphical modeling method and device, capable of quickly and precisely inferring a gene network from a manifestation profile. SOLUTION: The method includes steps in which a gene manifestation profile is inputted, correlation coefficient matrix for genes is calculated, cluster analysis is executed, a cluster analysis result is outputted, and the correlation coefficient matrix of representative genes is calculated. Then transformation into partial correlation coefficient matrix is executed, minimum elements are retrieved, inverse transformation into the correlation coefficient matrix is executed, and significance is determined. When there is no significance, as a result of significance judgment, operation is returned to the transformation into the partial correlation coefficient matrix, but when there is significance, a partial correlation coefficient matrix is outputted, to execute graphical modeling for inferring the gene network.