THERAPIES FOR SMOKE AND/OR BURN INDUCED LUNG INJURY

摘要

In accordance with the present invention there are provided therapies for lung injuries following smoke inhalation and thermal injuries. In particular, the invention relates to the use of antibodies, and more particularly human antibodies, as therapeutics of such injuries. In preferred aspects of the invention, antibodies that bind to interleukin-8 (IL-8) and/or L-selectin, alone, or in combination with other antibodies that bind to other pro-inflammatory, inflammatory, and anti-inflammatory moieties that are induced in lung and burn lesions. In particularly preferred embodiments of the invention, human antibodies that bind to IL-8 are utilized and are demonstrated herein to possess therapeutic efficacy in in vivo models of the pro-inflammatory, inflammatory, and anti-inflammatory moieties that are induced in lung and burn lesions.