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Method for finding nucleotide synthesis inhibitors having fewer side effects
Method for finding nucleotide synthesis inhibitors having fewer side effects
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机译:寻找副作用少的核苷酸合成抑制剂的方法
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摘要
The invention relates to a method for finding nucleotide synthesis inhibitors which have a better therapeutic window. An efficacious dose of a nucleotide synthesis inhibitor is administered to a mammal. The concentration of the nucleotide synthesis inhibitor in the blood of the mammal is observed and it is determined whether the nucleotide synthesis inhibitor has a half-life which is shorter than that of N-(4-trifluoromethylphenyl)-2-cyano-3-hydroxycrotonamide. The invention also relates to a method of using nucleotide synthesis inhibitors in the treatment of immunological diseases.
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