Pharmaceutical composition containing a cysteine protease inhibitor for prophylaxis and therapy of brain tissue impairment

摘要

A pharmaceutical composition for the prophylaxis and therapy of brain tissue impairment, which contains, as an active ingredient, a compound of the following formula (I) ;wherein R¹ represents an alkyl group having 1-4 carbon atoms or an aryl group having 6-10 carbon atoms which is optionally substituted; R² and R³ may be the same or different and each represents hydrogen or an alkyl group having 1-4 carbon atoms or R² and R³ may jointly form a ring having 3-7 carbon atoms; and R⁴ represents a lower alkyl group which is optionally substituted by aryl, cycloalkyl, or aromatic heterocyclic residue, or a pharmaceutically acceptable salt thereof.