Derivatives of imidazo 4,5-c - pyridin - 4 - ona, a process for their preparation, their use for preparing a Drug, The Drug base of these compounds.Pharmaceutical compositions containing these compounds and a process for preparing these compositions F

摘要

1. A new formulation of pyridan [4,5-c] - pyridine-4-ona (1) derivatives;wherein: R represents H, straight or branched chain C 1-6 alkyl or C 3-6 cycloalkyl; R1 represents Ar; R2 represents Ar; R3 represents H, R, R4, Hal, CN, COOH, COOA or CONH2; Ar and Ar independently represent phenyl, unsubstituted or mono, di or trisubstituted naphthyl obiphenyl with R, OH, Hal, CN, NO2, CF3, NH2, NHR, NR2, pyrrolidin-1-yl, piperidin-1-yl, benzyloxy, SO2NH2 , SO2NHR, SO2NR2, -CONHR, -CONR2, - (CH2) n-NH2, - (CH2) n-NHR, - (CH2) nNR2, -O- (CH2) n-NH2, -O- (CH2) n -NHR, -O- (CH2) n-NR2, R4 or jointly substituted with -O- (CH2) mO-; R4 represents -C (= NH) -NH2, -NH-C (= NH) -NH2 or -C (= O) -N = C (NH2) 2 unsubstituted or monosubstituted with -COR, -COOR,-OH o con un grupo protector de aminoconvencional formula (2) o (3)A C1-4 tar; Hal for F, Cl, Br or I; m for 1 or 2; n for 0, 1, 2 or 3; P for 0 or 1. 1. The procedure for the preparation of pyridine [4,5-c] - pyridine-4-ona (1) derivatives;Wherein: (a) they are released from a functional derivative by treatment with a Soviet or hydrogenolysis agent; or (b) a formula compound (1) converts one or more residual R, R1, R2 and / or R3 into one or more different R, R1, R2 and / or R3 residues; and / or converts one or more formula acids into their salts. 1. Preparation of drugs for disease prevention / treatment using chemically acceptable formula compounds (1) and / or SARS salts.