Compounds derived from acids 2,3,4,5 - tetrahydro - 1H - 1,4 benzodiazepine-3-carboxylic - hidroxamicos, Pharmaceutical composition containing same and use of same for the manufacture of a medicament

摘要

2,3,4,5-tetrahydro-1h - [1,4] benzodiazo-3-hydroxy compounds have the following formula (1), wherein R1, R2, R3, R4 and R have the meaning in descriptive memory. In addition, the pharmaceutical ingredients containing these ingredients are described, as well as the use of these ingredients to produce an effective drug for the treatment of maternal and TACE diseases of metal acrylonitrile, such as tumor growth, osteoarthritis, rheumatoid arthritis and the loss of degenerative cartilage.