Method for preparing Effervescent Granules comprising Iron gluconate, Granulate thus obtained and Tablets containing

摘要

Method for preparing Effervescent Granules comprising, as Active Ingredient, Pharmacological, Ferrous gluconate, and Effervescent System, Citric Acid and sodium bicarbonate.By Wet granulation in a fluidized bed Granulator, Said method comprising phases (i) are mixture comprising ferrous gluconate, Citric Acid and sodium bicarbonate.In the Granulator as it is FED with a Flow of airecalentado approximately 70sc and has a Moisture 10 g / kg; (ii) to moisten the mixture through water mist when it has reached a temperature of approximately 35sc; (iii) evaporate Water foggingKeeping the temperature of the mixture 35sc substantially Constant; (iv) repeat the phrases II and III until it has formed a pellet that has the desired characteristics; and (V) Dry.Ho Granules with heated air at roughly 80sc until its Moisture content of less than or equal to 0.5% by weight. Granulate thus obtained and Tablets that contain it.