2,4-DISUBSTITUTED TRIAZINE DERIVATIVES

摘要

The invention concerns the use of the compounds of formula the N-oxides, the pharmaceutically acceptable addition salts, quaternary amines and the stereochemically isomeric forms thereof, wherein -a1=a2-a3=a4- forms a phenyl, pyridinyl, pyrimidinyl, pyridazinyl or pyrazinyl with the attached group; n is 0 to 4; and where possible 5; R1 is hydrogen, aryl, formyl, C1-6 alkylcarbonyl, C1-6 alkyl, C1-6alkyloxycarbonyl or substituted C1-6 alkyl; each R2 independently is hydroxyl, halo, optionally substituted C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7cycloalkyl, C1-6 alkyloxy, C1-6 alkyloxycarbonyl, carboxyl, cyano, nitro, amino, mono- or di(C1-6 alkyl)amino, polyhalomethyl, polyhalomethyloxy, polyhalomethylthio, -S(=O)pR4, -NH-S(=O)pR4, -C(=O)R4, -NHC(O)H, -C(=O)NHNH2, -NHC(=O)R4, -C(=NH)R4 or a 5-membered heterocyclic ring; p is 1 or 2; L is optionally substituted C1-1) alkyl, C2-10 alkenyl, C2-10 alkynyl or C3-7 cycloalkyl; or L is -X-R3 wherein R 3 is optionally substituted phenyl, pyridnyl, pyrimidinyl, pyrazinyl or pyridazinyl; X is -NR1-, -NH-NH-, -N=N-, -O-, -C(=O)-, -S-, -CHOH-,-S-, -S(=O)- or -S(=O)2-; aryl is optionally substituted phenyl; for the manufacture of a medicine for the treatment of subjects suffering from HIV (Human Immunodeficiency Virus) infection. 13 claims, 1 figure