Use of a sex steroid analog that disrupts the sex steroid that signals the thymus, and composition to increase an immune response to an antigen

摘要

"USE OF A SEXUAL STEROID ANALOG THAT BREAKS THE SEXUAL STEROID THAT SIGNALS TO THE THYMUS, AND COMPOSITION TO INCREASE AN IMMUNE RESPONSE TO AN ANTIGEN". The present invention provides a method of modifying the constitution of the T-cell population or increasing the number of T-cells in an individual having depressed or abnormal T-cell population or function, the method comprising interrupting sexual steroid signaling. to the thymus in the individual. The invention can be used to treat an individual suffering from a wide range of diseases, for example, cancer, HIV infection, autoimmune disease and hypersensitivity. In addition, the present invention provides methods to increase an immune response to an antigen, to treat an autoimmune disease, and to decrease the receptor-graft reaction in a transplant donor.