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Stimulation of thymus for vaccination development through the use of a sex steroid blocker thus improving the immune system
Stimulation of thymus for vaccination development through the use of a sex steroid blocker thus improving the immune system
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机译:通过使用性类固醇阻滞剂刺激胸腺进行疫苗接种,从而改善免疫系统
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摘要
The present disclosure provides methods for enhancing the response of a patient's immune system to vaccination. This is accomplished by reactivating the thymus. Optionally, hematopoietic stem cells, autologous, syngeneic, allogeneic or xenogeneic, are delivered to increase the speed of regeneration of the patient's immune system. In a preferred embodiment the hematopoietic stem cells are CD34+. The patient's thymus is reactivated by disruption of sex steroid mediated signaling to the thymus. In a preferred embodiment, this disruption is created by administration of LHRH agonists, LHRH antagonists, anti-LHRH receptor antibodies, anti-LHRH vaccines or combinations thereof.
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