Compound, use of it, pharmaceutical composition and methods to inhibit thrombin and the formation of platelet and thrombus aggregates in the blood and to treat or prevent deep vein thrombosis and cardiogenic thromboembolism, cancer-associated thrombosis and chemotherapy of cancer and unstable angina in a mammal and stroke in humans and other mammals

摘要

"COMPOUND, USE OF THE SAME, PHARMACEUTICAL COMPOSITION AND METHODS TO INHIBIT THROMBIN AND THE FORMATION OF PLATELET AND THROMBO AGGREGATES IN THE BLOOD AND TO TREAT OR PREVENT DEEP VEIN THROMBOSIS AND COMBINED EMBODYRAMUS, CARDIOBULOSIS AND CARDIOBOSIS. CANCER CHEMOTHERAPY AND INSTALLABLE ANGINA IN A MAMMALIAN AND THE CEREBRAL VASCULAR ACCIDENT IN HUMAN AND OTHER MAMMALIAN BEINGS ". The compounds of the invention are useful in inhibiting thrombin and associated thrombotic occlusions having structure (I) where A is (II), (III) or (IV) where Y ^ 1 ^ and Y ^ 2 ^ are independently hydrogen, C ~ 1-4 ~ alkyl, C ~ 1-4 ~ alkoxy, F ~ u ~ H ~ v ~ (C (CH ~ 2 ~) ~ 0-1 ~ O-, where u and v are 1 or 2, provided that when u is 1, v is 2 and when u is 2, v is 1, C ~ 3-7 ~ cycloalkyl, C ~ 1-4 ~ alkylthio, C ~ 1-4 ~ sulfonylalkyl, halogen, cyano or trifluoromethyl and where b is 0 or 1.