compound, pharmaceutical composition, methods for inhibiting blood thrombus formation or treating blood thrombus formation, preventing blood thrombus formation, treating venous thromboembolism and pulmonary embolism, treating deep vein thrombosis and treating thromboembolic attack , and, use of a compound

摘要

The present invention provides a compound of formula II and pharmaceutical compositions, comprising one or more of said compounds, and methods for using said compounds to treat or prevent thrombosis, embolisms, hypercoagulability or fibrotic disorders. The compounds are selective factor xia inhibitors or dual factor xia and plasma kallikrein inhibitors.