Aminotiazoles derived Compounds, Preparation Method, Pharmaceutical composition,Useful for treating a condition mediated by Activation of the Adenosine A2B receptor and / or the adenosine receptor A3 as obstructive and inflammatory diseases of the Airways.

摘要

Compounds of formula: in free form or in Salt,Where: R is a monovalent Aromatic Group of 6 to 15 carbon ATOMS, R1 is Hydrogen,PHENYL optionally substituted by one or more substituents selected from halogeno, cyano, hydroxyl, alkyl of 1 to 8 Carbon ATOMS, haloalquilo 1 to 8 Carbon Atoms.Alkoxyl of 1 to 8 Carbon ATOMS, alkoxyl of 1 to 8 Carbon Atoms - alkyl of 1 to 8 Carbon ATOMS, or aciloxilo or a monovalent Heterocyclic Group of 5 or 6 members.R2 is Hydrogen, alkyl of 1 to 8 Carbon ATOMS, or Acyl - (R3, R4), on the understanding that R2 is alkyl of 1 to 8 Carbon ATOMS, acyl, 6 - (R3) when R4, R1 is Hydrogen,R3 and R4 are each independently Hydrogen or alkyl of 1 to 8 Carbon Atoms.Or with the nitrogen Atom linked with heterocycle denote a group of 5 or 6 members, and Z1, Z2,Z3 and Z4 are each independently or CR5, being at least one of them and R5 is Hydrogen, CR5,Alkyl of 1 to 8 Carbon Atoms or alkoxyl of 1 to 8 Carbon Atoms. The compounds are useful as Pharmaceuticals.