N - Acyl - 2 - aminotiazoles replaced, a method for their preparation, Pharmaceutical compositions containing them and their use in the manufacture of a Medicament for the treatment of diseases mediated by the Adenosine A2B receptor antagonism.

摘要

Estos compuestos son utiles en el tratamiento de diabetes retinopat a diab tica asma y diarrea por su accion antagonista del receptor A2B de adenosina Reivindicac- (CH2) 3- y -O (CH2) -R is a tar composed of 5 or 6 saturated or unsaturated or unsaturated members, an alquenio, NHR 'or a carbon ring composed of 5 or 6 saturated or unsaturated polycyclic rings or members, optionally containing one or more heteroatoms, which are replaced by one or more substitutes selected from the halogenated, hydroxyl, low tar groups. 1. Acetyl methyl ether, alcoxicarbornil amidomedilo, a group of nitro compounds, a group of sulfur amides, asphalt, propoxy, benzene, benzoic acid, benzoate, benzoate or ammonium sulfite, which can be replaced by halogen, Trihalo low tar, low tar, alcoxi, aryl sulfite or cyanogen;R1 was selected from h, halogen, low tar, oxygen or a nitro group; R 'is a tar or carbon ring or aperiodic ring composed of 5 or 6 saturated or unsaturated members, which can optionally contain one or more heteroatoms and be replaced by one or more substitutes, lower tar, nitro group and tar group selected from the halogenation group, Alcoxi and ACIO ILO Convention No. 11: procedures for the processing of compounds in accordance with any ILO Convention No. 1-10, including reactions to a formula compound (1) containing R-C (or) Cl compound, where R,R1 and X are claims 1 to 10 as defined by any DS.