PURINE COMPOUNDS HAVING PDE IV INHIBITORY ACTIVITY, MEDICAMENTS CONTAINING THE SAME AND METHODS OF SYNTHESIS

摘要

The present invention relates to compounds of formula (I), to PDE IV inhibitor pharmaceutical compositions containing them, and to their preparation. In the formulas, Y1 and Y2 are CH and N; Z is -CH 2, -CH 2 CH 2, -CH (CH 3), -CH = CH, C = C, NH, N (C 1 -C 3 alkyl), O, S, C (O) CH 2 and OCH 2; R 1 and R 2 are hydrogen and C 1-8 straight or branched alkyl or C 3-8 cycloalkyl; R3 is straight or branched alkyl of 1 to 12 carbon atoms; R4 is C3-C10-cycloalkyl optionally substituted with hydroxy or C3-C10-cycloalkenyl optionally substituted with hydroxy; R 8 is C 1-8 straight or branched alkyl or C 3-8 cycloalkyl optionally substituted by hydroxy. The agents are useful in the treatment of asthma, allergy, inflammation, dementia, atopic disease, rhinitis and diseases associated with abnormally high physiological values of acitokines. HE