Purine compounds having PDE IV inhibitory activity and methods of synthesis

摘要

The present invention comprises compounds having the general formula I: chemistry chemdraw filechemistry mol file;wherein: ;Y₁ is N or CH ;Z is selected from the group consisting of alkyl groups such as alkylene groups such as CH₂, CH₂CH₂, CH(CH₃); alkenyl groups such as CH═CH; alkynyl groups such as C≡C; and NH, N(C₁-C₃ alkyl), O, S, C(O)CH₂ and OCH₂; ;R¹ and R² are selected from the group consisting of hydrogen and a C₁-C₈ straight or branched alkyl or a C₃-C₈ cycloalkyl; ;R³ is a C₁-C₁₂ straight or branched alkyl; ;R⁴ is a C₃-C₁₀ cycloalkyl optionally substituted with OH or C₃-C₁₀ cycloalkenyl optionally substituted with OH; and ;R⁸ is a C₁-C₈ straight or branched alkyl or a C₃-C₈ cycloalkyl, optionally substituted with OH; ;and methods of synthesis.