PHARMACEUTICAL COMPOSITIONS FOR TREATING BACTERIALLY INDUCED MENINGITIS CONTAINING PROSTANE DERIVATIVES

摘要

A pharmaceutical composition for treating bacterially induced meningitis, comprising an effective amount of a compound of the formula wherein X1 is a -CH2-CH2-, trans -CH=CH- or -C:C- group, X2 is a linear or branched saturated hydrocarbon chain having from 1 to 6 carbon atoms, X3 is an -O- or -CH2- group, X4 is a -CH2- or -(CH2)3- group, X5 is a hydrogen atom or a -C:C-R2 group, R1 is a hydrogen atom, an alkyl group having from 1 to 6 carbon atoms, a cycloalkyl group having 5 or 6 carbon atoms or a phenyl group, R2 is a linear or branched, saturated or unsaturated hydrocarbon chain having from 1 to 6 carbon atoms, R3 is a hydrogen atom, an acyl radical having from 1 to 4 carbon atoms or a benzyl radical, and R4 is a hydrogen atom or a methyl group, wherein the -O-R3- group is in the a or b-configuration, or a salt thereof with a physiologically tolerable base when R1 represents a hydrogen atom, or a clathrate thereof.