Polynucleotide; vector; recombinant cell; polypeptide; antibody; composition; composition prepared by a process; use of composition; method for preparing a composition; method for preparing an antibody composition; method for inducing an immune response in a mammal; and method for preventing or treating bacterial meningitis in a mammal.

摘要

The present invention relates to Neisseria ORF2086 proteins, crossreactive immunogenic proteins which can be isolated from nesserial strains or prepared recombinantly, including immunogenic portions thereof, biological equivalents thereof, antibodies that immunospecifically bind to the foregoing and nucleic acid sequences encoding each of the foregoing, as well as the use of same in immunogenic compositions that are effective against infection by Neisseria meningitidis serogroup B.