Indirubina aril derivatives for replacement and their preparation and use

摘要

The substance refers to a formula derivative, wherein: R1, R2, R3, R4, R5 are h, oh, alcoxi C1-C6, ariloxi, trifluometilo, Niro, halogeno, Ciano, sopr6, so2nr7r8, cor9, arilo, optional heterosexual, replaced by hydrogen Xi, halogen, C1-C6 tar, amino, asphalt, tar, nitro, trifluoro, o-si-c1-c6, C4, COO C4, C1-C4, co-arilo C1-C4, SO2 tar layer C1-C4, SO2 arilo, Alcoy C1-C6, R3 are o, nor9, R1 and R2, or R4 and R5 can optionally form another ring of 3-6 members; R6 is h, C1-C18 tar, which can optionally be changed into halogen, hydroxyl, amino, arilo, heterosexual, c13-c8, R7 and R8, and C18 is C18.H, C1-C6 tar is selected from hydroxyl group, hydrogen halide, amino group, C1-C18, c1-cqilo c3-c8, cyclododecane c3-c8, R7 and R8, and N cyclododecane c3-c8, R9, instead of hydrogen Xi, carbon halide, alkane C1-C4, amino group, nitrous acid, trifluoroalkyl, cyanogen, coo-lo C14, c14-c4, c14-c4, c14-arlo-c4, So2-c1-c4, SO2 arilo, P is 0-2. These compounds are cyclohexyl streptococcal inhibitors, such as CDK1, CDK2, Cdk3, CDK4, Cdk5, which can be used to treat cancer, autoimmune diseases, aloe caused by chemotherapy, adhesives, cardiovascular diseases, infectious diseases, kidney disease, neurodegeneration.gallbladder