Process for preparation of pharmaceutical compositions for the deposition of complexes of farmacos and cyclodextrins on nucleos inert or active

摘要

The object of the present invention is a process for preparing pharmaceutical compositions comprising an inert or active core on which a complex consisting of a drug and cyclodextrin is deposited. Said process essentially comprises preparing a liquid phase consisting essentially of a natural or modified cyclodextrin solution in an appropriate solvent or solvent mixture; dissolving a certain amount of drug in the solution; eventually preparing a second liquid phase essentially consisting of a solution or suspension of a polymer in the same solvent; adding to one another, with stirring, the resulting liquid phases in order to immediately obtain a dispersed solution or suspension of the drug-cyclodextrin complex in the polymer; and spraying the resulting solution or suspension on the inert or active cores, and simultaneously eliminating the solvent by evaporation, in order to achieve the deposition of the complex on said inert or active cores.