DERIVATIVES OF QUINUCLIDINE AS ANTAGONISTS OF THE SUBSTANCE P.

摘要

USEFUL COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS, DISORDERS OF THE CENTRAL NERVOUS SYSTEM AND OTHER DISORDERS OF FORMULA (I) AND THE PHARMACEUTICALLY ACCEPTABLE SALTS OF THE SAME IN WHICH X1 IS ALCOXY OR ALCOXIAL; X2 is hydrogen, halogen, alkyl, alkenyl, alkynyl, alkoxy, alkylthio, alkylsulfinyl, alkylsulfonyl, Halosubstituted alkyl, alkoxy halosubstituted, alkylamino, dialkylamino, alkylsulfonylamino (which may be substituted), N-alkyl-N-alkylsulfonylamino (which may be substituted ), ALCANOILAMINO (WHICH CAN BE REPLACED) OR N-ALQUIL-NALCANOILAMINO (WHICH CAN BE REPLACED); AR1 AND AR2 ARE EACH, INDEPENDENTLY, TIENYL, PHENYL, FLUOFENYL, CHLOROPHENYL OR BROMOFENILO; A ES Y- (CH2) M-CH (R2) - (CH2) N-NR1-; R1 IS HYDROGEN, RENT, BENCILO OR - (CH2) P-Y; R2 IS HYDROGEN, RENT (WHICH CAN BE REPLACED), BENCILO, 4-HYDROXIBENCILE, 3-INDOLILMETILO OR - (CH2) P-Y; AND ES -CN, -CH2X OR -COZ; Z IS HYDROXY, AMINO, ALCOXI, RENT OR DIALQUILAMINE; M, N AND P ARE EACH, INDEPENDENTLY, 0, 1, 2 OR 3; AND R1 AND R2 CAN BE LINKED TO FORM A RING.