ISOLATED P27 PROTEIN AND ITS ENCODING NUCLEIC ACID MOLECULES

摘要

The subject invention provides an isolated protein having an apparent molecular weight of about 27 kD and capable of binding to andinhibiting the activation of a cyclin E-Cdk2 complex. The subject invention also provides the nucleic acid encoding the p27 protein, vectors,and host cells for producing the recombinant form of the p27 protein. The subject invention further provides methods for identifying agentscapable of modulating the ability of p27 to inhibit the activation of the cyclin E-Cdk2 complex. Finally, the subject invention providesmethods for treating subjects diagnosed with hypoproliferative disorders using said agents.