TRIAZOLOQUINAZOLINE AND PYRAZOLOTRIAZOLOPYRIMIDINE DERIVATIVES, PHARMACEUTICAL, COMPOSITION ADENOSINE A3 RECEPTOR AFFINITIVE AGENT, INTRAOCULAR-PRESSURE REDUCING AGENT, PHARMACEUTICAL PREPARATION FOR PREVENTION AND TREATMENT OF GLAUCOMA, AND INTRAOCULAR-PRESSURE REDUCING METHOD

摘要

Triazoloquinazoline and pyrazolotriazolopyrimidine derivatives represented bythe following general formula (1): (1) wherein R1 and R2 are each as definedin the description; and A represents a pyrazole or benzene ring optionallysubstituted by the group as cited in the description. These derivatives showan affinity for adenosine A3 receptor and an effect of lowering oculartension, which makes them useful in preventing or treating glaucoma.