HUMAN PHOSPHOLIPID SCRAMBLASE-LIKE MOLECULES AND USES THEREOF

摘要

Novel human phospholipid scramblase-like polypeptides, proteins, and nucleic acid molecules are disclosed. In addition to isolated, full-length human phospholipid scramblase-like proteins, the invention further provides isolated human phospholipid scramblase-like fusion proteins, antigenic peptides, and anti-human phospholipid scramblase-like antibodies. The invention also provides human phospholipid scramblase-like nucleic acid molecules, recombinant expression vectors containing a nucleic acid molecule of the invention, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a human phospholipid scramblase-like gene has been introduced or disrupted. Diagnostic screening, and therapeutic methods utilizing compositions of the invention are also provided.