Human nucleic acid sequences derived from breast tumor tissue

摘要

Human nucleic acid sequences from tumor breast tissue are new. A nucleic acid sequence that encodes (part of) a gene product comprises: (a) a nucleic acid sequence (I), chosen from a group of 32 sequences (fully defined in the specification); (b) an allelic variant (II) of (I); or (c) a nucleic acid sequence (III), that is complementary to (I) or (II). Independent claims are also included for: (1) a nucleic acid sequence (68 sequences fully defined in the specification), characterized in that it has increased expression in tumor breast tissue; (2) BAC, PAC and cosmid clones, containing functional genes and their chromosomal localization, corresponding to one of 76 sequences for use as vehicles for gene transfer; (3) a nucleic acid sequence comprising part of a sequence as above which is sufficiently large to hybridize to a sequence as above; (4) an expression cassette comprising a nucleic acid fragment or a sequence as above, together with at least a control or regulatory sequence; (5) a DNA fragment, comprising a gene, that is produced as a result of using a nucleic acid sequence as above; (6) a host cell containing genetic information for expression of a heterologous nucleic acid sequence as above; (7) a process for manufacturing a polypeptide or fragments, characterized in that the host cell above is cultivated; (8) an antibody against a polypeptide, which is encoded by a nucleic acid as above; (9) a polypeptide partial sequence having one of 60 sequences (fully defined in the specification); and (10) a genomic gene, its promoter, enhancer, silencer, exon and intron structure and splice variants, generated from cDNA having one of the 68 sequences.