A Method for Detecting Senescent Cell a Compostion for Restoring a Physiological Function of Senescent Cell and a Method for Restoring a Physiological Function of Senescent Cell Using Amphiphysin

摘要

PURPOSE: Provided are method for detecting senescent cells using amphiphysin 1 protein and its gene, a composition for restoring a physiological function of senescent cells and a method for restoring a physiological function of senescent cells. CONSTITUTION: The method for detecting senescent cells in mammal cells is characterized by measuring the decrease of amphiphysin 1 protein being in mammal cells with western blotting analysis, or by measuring the decrease of mRNA of amphiphysin 1 protein being in mammal cells with northern blotting analysis. The composition for restoring a physiological function of senescent cells contains an expression vector having amphiphysin 1 gene of SEQ ID NO:1 as an active ingredient. The physiological function of senescent cells can be restored by introducing the vector having amphiphysin 1 gene into senescent cells of a mammal.