2- 1- (1,3-thiazolin-2-yl) azetidin-3-yl thiocarbapenem derivative

摘要

The present invention provides a novel carbapenem compound, (1R, 5S, 6S) -2- [1- (1,3-thiazoline-2-yl) -azetidine-3-yl] thio-6-[(R )-1-hydroxyethyl]-1-methyl-carbafen-2-M-3-carboxylic acid derivatives.;These carbapenem compounds have a methyl group of β-configuration introduced at the 1-position and [1-(1,3-thiazoline-2-yl) azetidine-3 -yl] thio group introduced at the 2-position It is represented by a general formula.;Wherein R is hydrogen: hydroxy, lower alkoxy or lower alkoxy-lower alkoxy group substituted or unsubstituted lower alkyl group: group-COOR ¹ (R ¹ is hydrogen or lower alkyl group): or group-CONR ² R ³ ( R ² and R ³ are each independently hydrogen or a lower alkyl group.) And Y is a carboxy group, —COO ⁻¹ or a protected carboxy group.;These compounds are useful antibiotics for the prevention and treatment of bacterial infections.