STEROID COMPOUNDS (VARIANTS), PHARMACEUTICAL COMPOSITION, METHOD OF TREATMENT OF PATIENTS WITH NERVOUS DISORDERS (VARIANTS) AND METHOD OF ANESTHESIA INDUCTION IN ANIMAL

摘要

FIELD: organic chemistry, steroids, pharmacy. SUBSTANCE: invention describes steroid compounds of the general formula (I) where: a) R₄ means 3'-methyl-but-3'-ene-1'-inyl or cyclopro-pylethynyl; R₅ means methyl; R₆ means acetyl; dotted line means a single bond; b) R₄ means trifluoromethyl-group; R₅ means methyl; R₆ means acetyl; dotted line means a single or a double bond and in the case when this bond is a single one, R₆ is hydroxyacetyl and R₅ is hydrogen atom then R₄ can mean fluoromethyl-group; c) R₄- means ethynyl; R₅ means methyl; R₆ means hydroxymethyl or hydroxyacetyl; dotted line means a single bond, or their physiologically acceptable 21-esters, 3,20-diesters or 3,21-diesters or where: a) R₆ means hydroxyacetyl; R₅ means hydrogen atom in the case when R₄ is trifluoromethyl-group and compound is presented as sodium 21-hemisuccinate; b) R₆ means hydroxyacetyl; R₅ means methyl and R₄ can mean the following values: hydrogen atom in the case when compound is presented as bis-hemisuccinate; ethynyl in the case of 21-hemisuccinate; trifluoromethyl-group in the case of sodium 21-hemifumarate, methyl-21-succinate, 21-propionate; and c) R₄ means methyl; R₅ means methyl; R₆ means isopropylideneaminoethanol being dotted line means a single bond. Compounds of the formula (I) show ability to modulate excitability of GRC complex and therefore they can be used for treatment of patients with stresses, anxiety state, epileptic attack, mood disorders, premenstrual syndrome and post-delivery depression and for induction of anesthesia also. EFFECT: improved method of treatment and induction, valuable medicinal properties. 15 cl, 8 tbl, 31 ex