Use of chemically modified oligodeoxyribonucleotides for the suppression of the proliferation of human pancreatic tumors

摘要

The present invention relates to the use of in cell cultures of human pancreas tumors, and in in - vivo - to - scid mice, in which human pancreas tumor cells were implanted selected chemically modified oligo deoxyribonucleotides to apoptosis and for inhibiting the proliferation of the pancreas cancer cells. The chemical modification is effected by covalent terminal binding of lipophilic radicals or not - covalent immobilization of polymers and, as a rule, as a partially or continuously free sulfurized phosphorothioates.