New ureido-substituted dihydropyrimidinone derivatives, useful as broad-spectrum antibacterial agents with strong activity against Gram positive bacteria

摘要

5-(Diaminoalkanoylamino)-3,4,5,6-tetrahydro-2-(aryl-, aroyl-, alkyl- or alkoxycarbonyl-ureido)-pyrimidin-4-one derivatives (I) are new. Dihydropyrimidinones of formula (I) and their salts, solvates, hydrates and hydrated salts are new. R1 = H or T; A = -NR4R5, -NR5-C(Q)-NR6R7 or -N(R5)-C(R8)=NR9; R4 - R7, R9 = H, T, COT, benzyl or pyridylmethyl; R8 = H or T; Q = O, S or NR9; D = 2-6C alkanediyl (optionally substituted by 1 or 2 of OH, OT, OCOT or =O); E = direct bond or CH2; R2 = H or T; R3 = 6-10C aryl or (6-10C) aroyl (both optionally ring-substituted by 1 or 2 of halo, CF3 or T); 1-10C alkyl (optionally having one or more C replaced by O and optionally substituted by 1-3 of 6-10C aryl, COOT or COOH); or COOT; T = 1-6C alkyl. An Independent claim is included for the preparation of (I).