Synthetic peptide of human immunodeficiency virus type 1 (HIV-1) viral regulatory protein R (Vpr) and its application

摘要

The invention relates to synthetic (s) peptides of regulatory virus protein R (Vpr) of human immunodeficiency virus type 1(HIV-1), especially the total chemical synthesis of 96 aminoacid long Vpr protein (sVpr1-96), a 47 aminoacid long N terminal fragment (sVpr1-47) and a 49 aminoacid long C terminal fragment thereof (sVpr48-96) and to fragments sVpr1-20 and sVpr21-40, in addition to other fragments with approximately 15 aminoacids. Said products are used as HIV-1 regulatory proteins in biological assays and in the analysis of molecular structure and physico-chemical properties of Vpr and its domains or in the production of antibodies directed against Vpr-peptide sequences.