Synthetic peptide of regulatory virus protein R (VPR) of human immunodeficiency virus type 1 (HIV-1) and the utilization thereof

摘要

The invention pertains to synthetic (s) peptides derived from the viral regulatory protein R (Vpr) of the human immunodeficiency virus type 1 (HIV-1), particularly the chemical synthesis of the 96 amino acid full length Vpr protein (sVpr^1-96), of a 47 amino acid long N-terminal (sVpr^1-47), of a 49 amino acid long C-terminal fragment (sVpr^48-96) as well as fragments thereof (sVpr^1-20 and sVpr^21-40) and further approximately 15 amino acid long fragments of sVpr^1-96. As fragments or full length products of the HIV-1 regulatory protein, those products are used in biological assays, for molecular and structural characterization of Vpr and domains thereof, as well as for the development of anti-Vpr antibodies directed against Vpr peptide sequences.