Process for preparing trans-2,4-disubstituted piperidines

摘要

chemistry chemdraw file chemistry mol file The present invention provides a process for preparing a compound of formula (I), wherein R represents C₁-C₄ alkyl; and X represents an alkyl, alkenyl, cycloalkyl, aryl, substituted aryl, heterocycle, or substituted heterocycle, comprising treating a compound of formula (II), with a suitable crown ether and a suitable base followed by addition of a compound of formula R^−M^+ wherein M^+ is a suitable cation.