Synthesis of 2H1, 13C, 2H2, 13C and 2H3, 13Cmethyl aryl sulfides

摘要

The present invention is directed to labeled compounds, [²H₁, ¹³C], [²H₂, ¹³C] and [²H₃, ¹³C]methyl aryl sulfides wherein the ¹³C methyl group attached to the sulfur of the sulfide includes exactly one, two or three deuterium atoms and the aryl group is selected from the group consisting of 1-naphthyl, substituted 1-naphthyl, 2-naphthyl, substituted 2-naphthyl, and phenyl groups with the structure chemistry chemdraw filechemistry mol file;wherein R₁, R₂, R₃, R₄, and R₅ are each independently, hydrogen, a C₁-C₄ lower alkyl, a halogen, an amino group from the group consisting of NH₂, NHR and NRR′ where R and R′ are each a C₁-C₄ lower alkyl, a phenyl, or an alkoxy group. The present invention is also directed to processes of preparing [²H₁, ¹³C], [²H₂,¹³C] and [²H₃, ¹³C]methyl aryl sulfides wherein the ¹³C methyl group attached to the sulfur of the sulfide includes exactly one, two or three deuterium atoms. The present invention is also directed to the labeled compounds of [²H₁, ¹³C]methyl iodide and [²H₂, ¹³C]methyl iodide.