Synthesis and use of amino acid fluorides as peptide coupling reagents

摘要

The present invention is directed to the process of preparing a peptide comprising reacting a first amino acid or peptide with an amino acid fluoride of the formula: ;or the acid fluoride salts thereof wherein;BLK is an N-amino protecting group;;AA is an amino acid residue; and;X is absent or a protecting group.;The amino acid fluoride is useful as a coupling agent in peptide synthesis.