Compound of substituted polycyclic pirazinona Derivative, composition containing same and use of said composition, and said compound in the manufacture of Drugs useful for Selective inhibition of the coagulation Cascade

摘要

The Invention relates to compounds of aryl and heteroaryl substituted polycyclic - - pirazinonas formula (1) where the substituents are as defined in the specification and Claims,Useful as inhibitors of Serine proteases of the coagulation Cascade; Compounds, compositions and Use thereof in the manufacture of Drugs useful in the treatment and Prevention of various thrombotic diseases including coronary artery diseases and diseases cere Brovasculares.