Method for the treatment of migraines, using Selective Receptor Antagonists compounds iglur5,Use of selective antagonists of these compounds in the manufacture of medicaments for the treatment of migraines and these compounds are Antagonists

摘要

A method for treating or Preventing migraines which comprises administering to patients requiring such treatment effective amounts of iglur5 Selective antagonists of the receptors.Also described are Selective and functional compounds as antagonists of the receptors iglur5,Compositions and formulations comprising Selective antagonists of these receptors mentioned and Pharmaceutical salts thereof.A compound of the formula (1), and that each of R1 and R? Regardless is H, alkyl c1-20 alkyl, alquenilo C1 - C2 - 6, 6 - aryl alkyl, cycloalkyl C1 - C3 - 10 - 6, 6 - N - alkyl of C1.N-dialkyl alkyl Amine - 6 - C1, C1 - 6 - pyrrolidine, piperidine alkyl or alkyl of C1 - 6 - C1 - 6 - Morpholine, or a pharmaceutically acceptable Salt thereof.