Tiepino 3,2-b dihydropyridines, Pharmaceutical compositions that include, use of such compounds for preparing medicaments, apparatus for Administering Pharmaceutical compositions and processes for preparing these compounds

摘要

1. Tiepino [3, 2-B] dihydropyridine (1) or its pharmaceutically acceptable salts, wherein R1, R2, R3, R4 and R5 are independent of H, oh, halogen, cyanogen, NO2, tar, alcoxi c1-8, c1-8, hydrogen carbide C1-4, c1-8 pitch, difluoromethane, difluoromethy, difluoromethyleti and sulfur fluoride; e. Oxadiazol (composed of R1 and R2);X a n d y were selected from (a) R7 and R6; (b) R10 and (CH2) m-nr8r9; (c) R7 and R11; and (d) R10 and R11: H, C1-5 linear or separable tar, alternative tar, arilo, 3-piserial, 3-piterial n-replace, 2-pirrolidinil methyleno-replace, respectively; In this case, the 3-piseriallo n-permutation of the above 3-piseriallo n-permutation and the 3-piseriallo n-permutation of the 2-pirroilidinil methen-permutation can be replaced by the c1-8 of linear chain or branch or the c1-8 tar of benzene, and the alternatives can be replaced by Alcoy c1-8, alcoiloxi C2-8, fenilacetiloxi, benzoiloxi, halogeno, p-tosiloxi, mesiloxi, amino, carboacioxi,Where (I) r 'and R' are independent of group H; c1-8 is linear or isolated, c1-7 is cyclopropyl, phenyl, benzene and phenylethyl, or O (II) r 'and R' combine to form a heterocyclic ring, which is composed of piperidine, pirrolidino, morfolino, tiomorfolino, piperazino, 2-tieno, 3-tieno. a. The n-substitution of a heterocyclic derivative is replaced by H, c1-8 linear matrix or derivative, benzhidril, phenyl and / or phenyl (with NO2, halogenated, c1-8 linear or derivative, alcox c1-8 and / or trifluorometric);R7 was selected from arilo, 3-piridio, 2-tieno and 3-tieno, R8 was the last (CH2) P (isocycloethane) or (CH2) P (arilo);R9 is selected from h, asphalt, cyclopropyl compounds, arilo and arilalquilo; R10 is selected from h, amine, asphalt, arilo, sulfur trifluoride and alcoximetry; R11 is selected from the group consisting of the only asphalt - Oh, rental ore, lake, cyclic carbonate, cyclic carbonate, replaced by asphalt, cyclic carbonate, aril-c (o) or '. -Tar-aril-c (o) or ',alquil-OC (O) R-alquil-C (O) R-alquil-C (O) OR-alquil-N (R) C (O) RAnd the last one -- N ''c (o) o r',R '' and R '' were independently selected from the hydrogen, amine, tar, arilo, cyclopentadiene and non cyclopentene groups mixed with arilo, which contained amines mixed with halogen, cyanogen, NO2, lactona, amine, leased non cyclopentene, hydrocarbon, arilo, cyclopentadiene and non cyclopentene, 1. Arilo, Amida, carbamato, carbamoile, carboaco Circo, asphalt, asphalt, halogenated tar, arilalquilo, Alcoy, isopropene and / or arilo alternative asphalt (optional to be replaced by Oh, halogeno, Ciano, NO2, acquilo, amino, demitlamino, alcox, aculfonilo, carbonoxy C1-4, asphalt and / or trifluorometyl);And m, N and P are all in one from 1 to 5. Pharmaceutical compounds containing these compounds, compounds for drug preparation, management devices for drug synthesis and processes for the preparation of these compounds are also disclosed.