COMBINED COMPOSITIONS AGAINST TUMORS COMPRISING SUBSTITUTED ACRYLOYL DISTAMYCIN DERIVATIVES, TAXANES AND/OR ANTIMETABOLITED

摘要

The present invention relates to pharmaceutical compositions for use in antineoplastic therapy in mammals, including humans, comprising: - a pharmaceutically acceptable carrier or vehicle; - an acryloyl distamycin derivative of the formula (I) in which R1 is bromine or chlorine; and R2 is a distamycin or distamycin-like backbone or a pharmaceutically acceptable salt thereof; and - an antimicrotubule agent and / or a single antimetabolite. SHE