PHARMACEUTICAL COMPOSITIONS COMPRISING SUBSTITUTED ACRYLOYL DISTAMYCIN DERIVATIVES, TAXANES AND/OR ANTIMETABOLITES AND PRODUCTS COMPRISING SAME FOR COMBINED TREATMENT OF TUMORS

摘要

The present invention provides the combined use of acryloyl distamycin derivatives, in particular alpha-bromo- and alpha-chloro-acryloyl distamycin derivatives of formula (I), as set forth in the specification, and antimicrotubule agents. Also provided is the use of the said combination in the treatment or prevention of metastasis or in the treatment of tumors by inhibition of angiogcncsis.