ISOTOPICALLY LABELED ANALOGS OF TAXANE AND METHODS FOR THE PRODUCTION THEREOF

摘要

The present invention relates to isotopically labeled analogs of taxane molecules, which are synthetically formed to have incorporated therein at a selected position a stable isotope of an element existing at the selected position in the standard taxane molecule. The present invention also relates to methods of producing isotopically labeled taxane molecules, and methods of determining the retention of a target taxane in a biological material derived from an organism that has been dosed with the target taxane.