A process for the manufacture of a(11z,13z)-7,10-dihydro-10-hydroxy-retinyl acylate

摘要

A process for the manufacture of (UZ, 13Z)-7, lO-dihydro-lO-hydroxy-retinyl acylates comprises selectively monoacylating (UZ, 13Z)-7,10-dihydro-10-hydroxy- retinol in an organic solvent in the presence of an acylating agent with a lipase, especially of the enzyme class EC 3.1.1.3, which is present in suspension. In order to improve the accessibility to the lipase and its re-use, the lipase can be immobilized on various carrier materials. The immobilization can also be effected in the presence of a cholanic salt, e.g. sodium cholate or deoxycholate, by which means the activity can be increased to some extent. The process in accordance with the invention is outstandingly suitable for the manufacture of (IIZ, 13Z)-7,10- dihydro-10-hydroxy-retinyl acetate, an important startmg materia! for the production of vitamin A acetate, and this use as well as generally the use of a (1IZ, 13Z)-7, 10-dihydro-l0-hydroxy-retinyl acylate obtained in accordance with the invention for the production of the corresponding vitamin A acylate is a further aspect of the present invention. PRICE: THIRTY RUPEES