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Process for preparation of an oral controlled release pharmaceutical composition for once-a-day therapy for treatment and prophylaxis of cardiac and circulatory diseases
Process for preparation of an oral controlled release pharmaceutical composition for once-a-day therapy for treatment and prophylaxis of cardiac and circulatory diseases
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机译:每天一次治疗和预防心脏和循环系统疾病的口服控释药物组合物的制备方法
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摘要
The present invention relates to an oral controlled release pharmaceutical composition for once-a-day therapy for the treatment and prophylaxis of cardiac and circulatory diseases comprising carvedilol or its pharmaceutically acceptable salt or ester and release rate controlling excipients, wherein the said composition is adapted to release the carvedilol in a controlled manner so as to provide control over carvedilol plasma levels, such that the ratio of peak plasma levels to the plasma levels at 24 hours after administration, and the mean residence time of carvedilol, are within a desirable range for said once-a-day therapy for the treatment and prophylaxis of cardiac and circulatory diseases.
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